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Experts from the Western Balkans and Türkiye attend the Annual Meeting and Large Capacity-building Workshop of the European Reference Laboratory Network for Tuberculosis in Bratislava, Slovakia

ECDC - News - Thu, 09/12/2024 - 15:12
The second ERLTB-Net Annual Meeting and Large Capacity-building Workshop took place on 4−6 September 2024 in Bratislava, hosted by ECDC and consortium members.
Categories: C.D.C. (Europe)

WHO analysis highlights vast unmet rehabilitation needs in Gaza

WHO news - Thu, 09/12/2024 - 11:38

At least one quarter or 22 500 of those injured in Gaza by 23 July are estimated to have life-changing injuries that require rehabilitation services  now and for years to come, according to a  World Health Organization (WHO) analysis of the types of injuries resulting from the ongoing conflict in Gaza: Estimating Trauma Rehabilitation Needs in Gaza using Injury Data from Emergency Medical Teams.  

The analysis found that severe limb injuries, estimated to be between 13 455 to 17 550, are the main driver of the need for rehabilitation. Many of those injured have more than one injury. According to the report, between 3105 and 4050 limb amputations have also occurred. Large surges in spinal cord injury, traumatic brain injury and major burn injuries all contribute to the overall number of life-changing injuries, which includes many thousands of women and children.

“The huge surge in rehabilitation needs occurs in parallel with the ongoing decimation of the health system,” said Dr Richard Peeperkorn, WHO Representative in the occupied Palestinian territory. “Patients can’t get the care they need. Acute rehabilitation services are severely disrupted and specialized care for complex injuries is not available, placing patients' lives at risk. Immediate and long-term support is urgently needed to address the enormous rehabilitation needs.” 

Currently, only 17 of 36 hospitals remain partially functional in Gaza, while primary health care and community-level services are frequently suspended or rendered inaccessible due to insecurity, attacks, and repeated evacuation orders. Gaza’s only limb reconstruction and rehabilitation center, located in Nasser Medical Complex and supported by WHO, became non-functional in December 2023 due to lack of supplies and specialized health workers being forced to leave in search of safety, and was later left damaged following a raid in February 2024. Tragically, much of the rehabilitation workforce in Gaza is now displaced. Reports indicate 39 physiotherapists have been killed as of 10 May. In-patient rehabilitation and prosthetic services are no longer available and the number of people with injuries requiring assistive products far exceeds the equipment available within Gaza. Partners report that stocks of essential assistive products such as wheelchairs and crutches have run out and it is difficult to replenish supplies due to the restricted flow of aid into Gaza.   

The analysis focuses solely on new injuries sustained since the escalation of hostilities in October 2023. However, tens of thousands of Palestinians in Gaza were already living with pre-existing chronic conditions and impairments before this, putting them at significant risk due to the lack of appropriate services. 

The estimates in the analysis will be used by WHO and partners to plan for a surge in rehabilitation-related services and contribute to long-term health planning and policymaking. 

Amidst the ongoing hostilities, it is critical to ensure access to all essential health services, including rehabilitation to prevent illness and death. WHO reiterates its call for a ceasefire, which is critical for rebuilding the health system to cope with escalating needs. 

 

High-level mission to Sudan reaffirms WHO commitment, calls for urgent action to address and end the extreme health and humanitarian crisis

WHO news - Mon, 09/09/2024 - 15:43
WHO Director-General Dr Tedros Adhanom Ghebreyesus and Regional Director Dr Hanan Balkhy yesterday concluded a two-day mission to Port Sudan, where they reaffirmed WHO's commitment to reaching all Sudanese in need and called on the international community to urgently act to end the extreme health and humanitarian crisis.

World Field Epidemiology Day 2024: Highlighting the power of collaboration

ECDC - News - Sat, 09/07/2024 - 13:00
This year, World Field Epidemiology Day focuses on the importance of collaboration in tackling global health challenges.
Categories: C.D.C. (Europe)

First phase of polio campaign concludes successfully in Gaza

WHO news - Wed, 09/04/2024 - 23:42

Over 187 000 children under ten years of age were vaccinated with novel oral polio vaccine type 2 (nOPV2) in central Gaza during the first phase of a two-round polio vaccination campaign, conducted between 1–3 September 2024. Vaccination coverage in this phase exceeded the initial estimated target of 157 000 children due to population movement towards central Gaza, and expanded coverage in areas outside the humanitarian pause zone.  

To ensure no child is missed in this area, polio vaccination will continue at four large health facilities in central Gaza over the next few days. Vaccine doses have been supplied to these sites to meet any additional needs. 

“It has been extremely encouraging to see thousands of children being able to access polio vaccines, with the support of their resilient families and courageous health workers, despite the deplorable conditions they have braved over the last 11 months. All parties respected the humanitarian pause and we hope to see this positive momentum continue,” said Dr Richard Peeperkorn, WHO Representative for the occupied Palestinian territory.

The first phase of the campaign was conducted by 513 teams, consisting of over 2180 health and community outreach workers. Vaccination was provided at 143 fixed sites, including hospitals, medical points, primary care centres, camps where displaced people are living, key public gathering spaces such as temporary learning spaces, food and water distribution points, and transit routes leading from central towards northern and southern Gaza. Additionally, mobile teams visited tents and hard to-reach areas to ensure they reached families who were unable to visit fixed sites. The presence of a substantial number of children eligible for vaccination who were unable to reach vaccination sites due to insecurity, necessitated special missions to Al-Maghazi, Al-Bureij and Al-Mussader – areas just outside of the agreed zone for the humanitarian pause.  

Preparations are underway to roll out the next phase of the campaign, which will be conducted in southern Gaza from 5–8 September 2024, targeting an estimated 340 000 children below ten years of age. Some 517 teams, including 384 mobile teams, will be deployed. Nearly 300 community outreach workers have already begun outreach to families in southern Gaza to raise awareness about the campaign, while 490 vaccine carriers, 90 cold storage boxes, and other supplies have been transferred to Khan Younis for distribution to vaccination sites. 

The third and last phase of the polio vaccination campaign will be implemented in northern Gaza from 9–11 September 2024, targeting around 150 000 children.  

At least 90% vaccination coverage during each round of the campaign is needed to stop the outbreak, prevent the international spread of polio and reduce the risk of its re-emergence, given the severely disrupted health, water and sanitation systems in the Gaza Strip. Vaccination coverage will be monitored throughout the campaign, and, when necessary, vaccinations will be extended to meet coverage targets as part of flexible strategies to ensure every eligible child receives their vaccine dose. 

The two-round campaign, being conducted by the Palestinian Ministry of Health (MOH), in collaboration with the World Health Organization (WHO) and United Nations Children Fund (UNICEF), the United Nations Relief and Works Agency for Palestine Refugees (UNRWA) and many partners, aims to provide two drops of nOPV2 to around 640 000 children during each round. 

"The successful delivery of the first phase of the campaign in central Gaza is a culmination of immense coordination among various partners, including the Global Polio Eradication Initiative (GPEI) and donors, and underscores the importance of peace for the health and well-being of people in Gaza. We call on all parties to continue fulfilling their commitment to the humanitarian pauses as the second phase of the campaign begins tomorrow,” said Dr Peeperkorn. 

 

Notes to editors 

  • The campaign is part of an urgent response to prevent the spread of polio after circulating variant poliovirus type 2 (cVDPV2) was detected in Gaza, after 25 years of being polio-free. cVDPV2 has been detected in six environmental samples – or wastewater – collected from central Gaza in June 2024. Gaza has reported four cases of children with acute flaccid paralysis (AFP), including one case of confirmed polio in a child who tested positive for circulating variant poliovirus type 2 (cVDPV2). Two of the reported cases tested negative for poliovirus. Laboratory results are pending on samples from the fourth AFP case.  
  • Novel oral polio vaccine (nOPV2) is a polio vaccine being used to stop transmission of variant poliovirus type 2 (cVDPV2), currently the most prevalent form of the variant poliovirus. 
  • nOPV2 is safe and effective and offers protection against paralysis and community transmission. It is the vaccine globally recommended for variant type 2 poliovirus outbreaks – the type that has been found in the recent samples from Gaza. 

WHO launches global framework for understanding the origins of new or re-emerging pathogens

WHO news - Wed, 09/04/2024 - 18:02

With the support of the Scientific Advisory Group for the Origins of Novel Pathogens (SAGO), the World Health Organization (WHO) has published a global framework to help Member States comprehensively investigate the origins of new and re-emerging pathogens. While there are a number of tools available for investigating infectious disease outbreaks, this is the first unified, structured approach to investigating the origins of a novel pathogen. This framework aims to fill that gap by providing a comprehensive set of scientific investigations and studies. It is the first version of a “how-to” guide that will be updated as and when needed, based on feedback from users.

As each outbreak and pandemic demonstrates, human and animal health is threatened by the increasing risk of the emergence of known (such as Ebola, Nipah, avian influenza, Lassa and Monkeypox viruses) and novel pathogens with epidemic and pandemic potential (novel influenza, MERS-CoV, SARS-CoV-1, SARS-CoV-2), the ability to prevent, and when we cannot prevent, to swiftly contain outbreaks and identify their origins is scientifically, morally, and financially more critical than ever.

The WHO global framework outlines scientific investigations and studies for six technical elements:

  • Early investigations of the first identified cases/ clusters / outbreaks to identify potential sources of exposure, collection of samples at the source, define the characteristics of the novel pathogen involved for establishment of diagnostic assays.
  • Human studies: to understand the epidemiology including clinical presentation, modes of transmission, pathology and earliest presence in syndromic surveillance samples. 
  • Human/Animal interface studies to identify potential animal reservoirs, intermediate hosts and reverse zoonoses.
  • studies to identify insect vectors or other sources of infection as well as earliest presence in the environment.  …
  • Genomics and Phylogenetics studies to identify precursor strains, genomic characteristics, evolution in intermediate hosts and humans and spatial distribution over time.
  • Biosafety/Biosecurity studies to determine if a breach in laboratory or research activities may have been associated with the first cases.

The WHO Global framework has been designed as a resource for scientists, researchers, public health authorities, and investigators in Member States. It provides guidance when and how to initiate such multi-disciplinary investigations and offers recommendations to countries on the capacities and tools needed to successfully implement them.  This includes the capacities needed such as human resources, human, animal, and environmental surveillance systems; biosafety and biosecurity regulations; and laboratories with testing and sequencing expertise – and the importance of sharing the findings of such investigations as soon as possible to guide next steps. These recommendations were developed to align with the International Health Regulations (IHR) and using a One Health approach.

Timely and comprehensive investigations into pathogens’ origins are critical for preventing and containing global health crises. The findings from such investigations provide the basis for stopping outbreaks before they begin, halting transmission chains and reducing the risk of pathogen spillover from animals to humans.  They also can confirm or exclude the possibility of an unintentional breach in laboratory biosafety and biosecurity.

To achieve this, is it critical for countries to conduct these are sharing initial findings in a rapid, complete and transparent manner as soon as results are available to ensure the implementation of measures to mitigate further transmission and prevent new spillover events and, eventually, future pandemics.

“Understanding when, where, how and why epidemics and pandemics begin is both a scientific imperative, to prevent future outbreaks, and a moral imperative for the sake of those who lose their lives to them,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. “This framework provides for the first time comprehensive guidance on the studies that are needed to investigate the origins of emerging and reemerging pathogens. If it had been in place when COVID-19 struck, the quest to understand its origins may have been less contentious and more successful. WHO continues to call on China to share all information it has on the origins of COVID-19, so that all hypotheses can be investigated.”

Established in November 2021 and made up of independent experts from around the world, the SAGO was tasked with identifying the best technical and scientific approaches to understanding the origins of emerging and re-emerging pathogens and developing this global framework. The SAGO forms part of a strengthened health emergency preparedness and prevention system developed by WHO, its Member States and many health and scientific partners.

 

ECDC experts contribute to the validation of the training materials for Africa CDC's Public Health Emergency Management Fellowship

ECDC - News - Wed, 09/04/2024 - 14:12
ECDC played an important role in a recent workshop to validate the training materials for the Africa Centres for Disease Control and Prevention (Africa CDC)'s Public Health Emergency Management Fellowship.
Categories: C.D.C. (Europe)

Fellows complete 2024 Project Review Module

ECDC - News - Wed, 09/04/2024 - 13:59
The 2024 Project Review Module, hosted by the Instituto Nacional de Saúde Doutor Ricardo Jorge (INSA) in Lisbon, Portugal, has successfully concluded, providing valuable insights and experiences to its 118 participants.
Categories: C.D.C. (Europe)

Data show marked increase in annual cholera deaths

WHO news - Wed, 09/04/2024 - 13:30

The World Health Organization (WHO) has published global cholera statistics for 2023, showing an increase in cases and deaths.  

The number of reported cholera cases increased by 13% and deaths by 71% in 2023 compared to 2022. Over 4000 people died last year from a disease that is preventable and easily treatable. 

Forty-five countries reported cases, an increase from 44 the previous year and 35 in 2021. Thirty-eight per cent of the reported cases were among children under five years of age.  

Cholera is an acute intestinal infection spread through contaminated food and water. Communities with limited access to sanitation are most affected. 

Conflict, climate change, inadequate safe water and sanitation, poverty, underdevelopment, and population displacement due to emerging and re-emerging conflicts and disasters from natural hazards all contributed to the rise in cholera outbreaks last year. 

The geographical distribution of cholera changed significantly from 2022 to 2023, with a 32% decrease in cases reported from the Middle East and Asia, and a 125% increase in Africa. Many countries in Africa reported a high proportion of community deaths, indicating gaps in access to treatment. 

This is the first year that multiple countries have reported deaths from cholera which occurred outside of health facilities, known as ‘community deaths’. In five out of 13 reporting countries, over a third of cholera deaths occurred in the community, highlighting serious gaps in access to treatment and the need to strengthen this area of response. 

Afghanistan, the Democratic Republic of the Congo, Malawi and Somalia continued to report large outbreaks of over 10 000 suspected or confirmed cases, with Ethiopia, Haiti, Mozambique and Zimbabwe adding to the tally in 2023. 

Preliminary data show that the global cholera crisis continues into 2024, with 22 countries currently reporting active outbreaks. Although the number of cases reported so far in 2024 is lower compared to the same period last year, 342 800 cases and 2400 deaths have already been reported to WHO across all continents as of 22 August.  

The increased demand for cholera materials such as oral cholera vaccines (OCV), diagnostic tests and essential medications like oral rehydration salts and intravenous fluids for rehydration persists into 2023, posing a challenge for disease control efforts globally. Since October 2022, the International Coordinating Group (ICG), which manages emergency vaccine supplies, has suspended the standard two-dose vaccination regimen in cholera outbreak response campaigns, adopting a single-dose approach instead in order to reach and protect more people given limited supplies. 

Despite the low stockpile of OCV, a record 35 million doses were shipped last year, with the one-dose strategy in effect. While vaccination is an important tool, safe drinking water, sanitation and hygiene remain the only long-term and sustainable solutions to ending cholera outbreaks and preventing future ones.  

WHO considers the current global risk from cholera as very high and is responding with urgency to reduce deaths and contain outbreaks in countries around the world. WHO continues to support countries through strengthened public health surveillance, case management, and prevention measures; provision of essential medical supplies; coordination of field deployments with partners; and support for risk communication and community engagement. 

US$ 18 million has been released from the WHO Contingency Fund for Emergencies for cholera response since 2022. WHO has appealed for US$ 50 million to respond to cholera outbreaks in 2024, but this need remains unmet. 

World Sexual Health Day 2024 - Actions needed to limit the spread of sexually transmitted infections in Europe

ECDC - News - Wed, 09/04/2024 - 13:00
On World Sexual Health Day, the European Centre for Disease Prevention and Control (ECDC) will publish a comprehensive review that underscores the urgent need to improve monitoring data and enhance targeted prevention interventions across Europe.
Categories: C.D.C. (Europe)

The Republic of Korea and WHO discuss joint priorities, challenges and trends around global health

WHO news - Wed, 09/04/2024 - 12:19

The World Health Organization (WHO) and the Republic of Korea have a long-standing partnership spanning over 75 years. As a result of their fruitful collaboration, there has been significant progress in health and development all around the world. The Republic of Korea has gone from being a donor-recipient country to a donor-country and is now a leader in global health and playing a critical role on the world stage.

Dr Catharina Boehme, Assistant Director-General for External Relations and Governance (WHO) and Dr Hye-Jin Kim, Deputy Minister for Planning and Coordination (Ministry of Health and Welfare, Republic of Korea), together with counterparts from WHO and the Government of the Republic of Korea.

To further strengthen this partnership and our commitment to working jointly to address global health challenges, WHO and the Republic of Korea convened their second Strategic Dialogue in Seoul from 28 to 29 August 2024. Dr Catharina Boehme, Assistant Directory-General for External Relations and Governance, led the WHO delegation and was accompanied by an in-person team and colleagues participating virtually from the three levels of the Organization (headquarters, regional, and country offices).

Dr Hye-Jin Kim, Deputy Minister for Planning and Coordination, Ministry of Health, led the Republic of Korea delegation and was joined by senior officials including Dr Young-Mee Jee, Commissioner, Korea Disease Control and Prevention Agency, as well as senior counterparts from the Ministry of Foreign Affairs, and the Ministry of Food and Drug Safety.

In addition, in line with WHO's work to enhance collaboration with parliamentarians, the WHO delegation also met with various Members of the National Assembly that are championing the global health agenda.

The recently concluded two-day meeting resulted in an alignment of priorities and paved the way for enhanced collaboration between WHO and the Government of Korea.

WHO delegation with Mr Jonghan Park, Director-General, Development Cooperation (Ministry of Foreign Affairs) - holding up the WHO Investment Case report

New global guidance aims to curb antibiotic pollution from manufacturing

WHO news - Tue, 09/03/2024 - 10:46
The World Health Organization (WHO) has published its first-ever guidance on antibiotic pollution from manufacturing.

UNICEF issues emergency tender to secure mpox vaccines for crisis-hit countries in collaboration with Africa CDC, Gavi and WHO

WHO news - Mon, 09/02/2024 - 22:56

UNICEF today announced that it has issued an emergency tender for the procurement of mpox vaccines. Vaccines can play a critical role in containing the mpox outbreak which was declared a public health emergency by both the Africa Centres for Disease Control and Prevention (Africa CDC) and the World Health Organization (WHO).

The UNICEF tender is issued to help secure mpox vaccines for the hardest hit countries in collaboration with Africa CDC, Gavi, the Vaccine Alliance, WHO, the Pan American Health Organization and other partners. This collaboration to increase access and timely allocation also includes working together to facilitate donations of vaccines from existing stockpiles in high-income countries with the aim of containing the ongoing transmission of mpox.

Under the emergency tender, UNICEF will set up conditional supply agreements with vaccine manufacturers. This will enable UNICEF to purchase and ship vaccines without delay once countries and partners have secured financing, confirmed demand and readiness, and the regulatory requirements for accepting the vaccines are in place. WHO is currently reviewing the information submitted by manufacturers on 23 August and is expected to complete its review for Emergency Use Listing by mid-September.

More than 18 000 suspected cases of mpox, including 629 deaths, have been reported this year in the Democratic Republic of the Congo which is at the epicentre of the crisis. Four out of five deaths have been in children.

“Addressing the current mpox vaccine shortage and delivering vaccines to communities who need them now is of paramount importance. There is also a pressing need for a universal and transparent allocation mechanism to ensure equitable access to mpox vaccines,” said Director of UNICEF Supply Division Leila Pakkala.

“As we confront the ongoing mpox outbreak, the timely procurement and distribution of vaccines is crucial to protecting the most vulnerable populations, particularly in the hardest-hit regions. This emergency tender is a critical step forward in our collective effort to control the spread of this disease. Africa CDC is committed to ensuring that vaccines are allocated swiftly and equitably across the continent, in partnership with UNICEF, Gavi, WHO, and other key stakeholders. Our unified response is essential to curbing the impact of this public health emergency and safeguarding the health and well-being of our communities,” said Dr. Jean Kaseya, Director General of Africa CDC.

“With several partners working on securing access to supply, today’s announcement represents an important step in this emergency, enabling UNICEF to purchase and deliver vaccines after Gavi and other partners make funding available and sign purchase or donation agreements with manufacturers for the most immediate dose needs,” said Dr Derrick Sim, interim Chief Vaccine Programmes and Markets Officer at Gavi, the Vaccine Alliance. “Securing access to supply and financing, delivering doses, and in parallel ensuring countries are ready to administer them, are all vital actions that need to be conducted rapidly but thoroughly, and in a coordinated manner. We welcome this tender as another positive step our Alliance and Africa CDC are taking in this response.”

“A swift, coordinated, and equitable response is critical to controlling the current mpox emergency and preventing future ones,” said Dr Maria Van Kerkhove, WHO incident manager for the global mpox response and acting Director for Epidemic and Pandemic Preparedness and Prevention. “All of us must act decisively now or risk allowing mpox to spread further and become an even greater global threat. In an interconnected world, the fight against mpox – as with other infectious diseases and health threats – cannot be waged alone., WHO is glad to partner with UNICEF, Gavi, Africa CDC, other partners and affected countries to get life-saving tools to people in need.”

The emergency tender is designed to secure immediate access to available mpox vaccines as well as to expand production. Depending on demand, production capacity of manufacturers and funding, agreements for up to 12 million doses through 2025 can be put in place.

Vaccines are one of several tools used to interrupt transmission and to protect children and communities against mpox. Africa CDC, Gavi, UNICEF, WHO, and partners are also prioritizing infection prevention and control, and risk communication and community engagement. As part of this, UNICEF is deploying personal protection equipment, diagnostic tests, medical treatment kits, hygiene supplies and tents to countries at the forefront of the crisis. These supplies support a host of medical countermeasures such as treatment, case isolation and surveillance.

UNICEF is the world’s largest single vaccine buyer, procuring more than 2 billion doses of vaccines annually for routine child immunization and outbreak response on behalf of nearly 100 countries.

 

About UNICEF

UNICEF works in some of the world’s toughest places, to reach the world’s most disadvantaged children. Across more than 190 countries and territories, we work for every child, everywhere, to build a better world for everyone.

About Africa CDC

The Africa Centres for Disease Control and Prevention (Africa CDC) is a continental autonomous public health agency of the African Union that supports member states in efforts to strengthen health systems and improve surveillance, emergency response, and prevention and control of diseases.

About Gavi, the Vaccine Alliance

Gavi, the Vaccine Alliance is a public-private partnership that helps vaccinate more than half the world’s children against some of the world’s deadliest diseases. The Vaccine Alliance brings together developing country and donor governments, the World Health Organization, UNICEF, the World Bank, the vaccine industry, technical agencies, civil society, the Bill & Melinda Gates Foundation and other private sector partners. 

Since its inception in 2000, Gavi has helped to immunise a whole generation – over 1 billion children – and prevented more than 17.3 million future deaths, helping to halve child mortality in 78 lower-income countries. Gavi also plays a key role in improving global health security by supporting health systems as well as funding global stockpiles for Ebola, cholera, meningococcal and yellow fever vaccines. After two decades of progress, Gavi is now focused on protecting the next generation, above all the zero-dose children who have not received even a single vaccine shot. The Vaccine Alliance employs innovative finance and the latest technology – from drones to biometrics – to save lives, prevent outbreaks before they can spread and help countries on the road to self-sufficiency.

About WHO

Dedicated to the well-being of all people and guided by science, the World Health Organization leads and champions global efforts to give everyone, everywhere an equal chance at a safe and healthy life. We are the UN agency for health that connects nations, partners and people on the front lines in 150+ locations – leading the world’s response to health emergencies, preventing disease, addressing the root causes of health issues and expanding access to medicines and health care. Our mission is to promote health, keep the world safe and serve the vulnerable.

Epidemiological update – Week 35/2024: Mpox due to monkeypox virus clade I

ECDC - News - Mon, 09/02/2024 - 12:22
Since the beginning of mpox monitoring in 2022 and until 31 July 2024, 102 977 confirmed cases of mpox due to MPXV clade I and clade II, including 219 deaths, have been reported by 121 countries globally, according to WHO (2022-24 Mpox (Monkeypox) Outbreak: Global Trends (shinyapps.io)). All cases of MPXV clade I have been reported from the African continent apart from one reported by Sweden and one by Thailand.
Categories: C.D.C. (Europe)

ECDC hosts Africa CDC for mass gathering monitoring training

ECDC - News - Fri, 08/30/2024 - 15:05
From 5 to 9 August 2024, ECDC welcomed colleagues from the Africa CDC Epidemic Intelligence Team for a week-long shadowing programme in Stockholm.
Categories: C.D.C. (Europe)

WHO urges rapid access to mpox diagnostic tests, invites manufacturers to emergency review

WHO news - Thu, 08/29/2024 - 19:47

WHO has asked manufacturers of mpox in vitro diagnostics (IVDs) to submit an expression of interest for Emergency Use Listing (EUL). WHO has been in ongoing discussions with manufacturers about the need for effective diagnostics, particularly in low-income settings. The request for EUL expressions of interest by manufacturers is the latest development in these discussions.

Testing is key for people to get treatment and care as early as possible and prevent further spread. Since 2022, WHO has delivered around 150 000 diagnostic tests for mpox globally, of which over a quarter have gone to countries in the African Region. In the coming weeks, WHO will deliver another 30 000 tests to African countries.

With as many as 1000 suspected cases reported in the Democratic Republic of the Congo alone this week, the demand for diagnostic tests is on the rise. In this heavily affected country, WHO has worked with partners to scale up diagnostic capacity to respond to the upsurge of cases. Since May 2024, six additional labs have been equipped to diagnose mpox, enabling a decentralization of testing capacity from major cities to affected provinces. Two of these labs are in South Kivu, selected to respond to the outbreak of the new viral strain, called Ib. Thanks to these efforts, testing rates have dramatically improved in the country, with four times as many samples tested in 2024 so far as compared to 2023.

WHO has also updated its diagnostic testing guidance to detect the new virus strain and is working with countries to roll it out. Earlier, WHO issued target product profiles to guide manufacturers in the development of new diagnostic tests.

WHO Director-General Dr Tedros Adhanom Ghebreyesus declared on 14 August 2024 that the upsurge of mpox in the Democratic Republic of the Congo (DRC) and in a growing number of countries in Africa constitutes a public health emergency of international concern (PHEIC) under the International Health Regulations (2005).

Manufacturers of IVDs are now asked to submit available quality, safety and performance data to WHO as soon as they can. IVDs are tests done in laboratories to detect a pathogen. Detection of viral DNA by PCR (Polymerase Chain Reaction) testing is the gold standard for mpox diagnosis. It detects the virus's DNA in samples taken from skin lesions, such as fluid or crusts from vesicles or pustules. Testing of blood is not recommended for routine diagnosis and antibody detection methods may be used for retrospective case classification but not for diagnosis.

Through the EUL procedure, WHO can approve medical products such as vaccines, tests and treatments for use, evaluating the acceptability of using specific products for time-limited procurement in emergency situations. The process aims to assist countries, which have not approved the medical products through national approval processes, to procure the critically needed products such as tests through UN agencies and other partners.

Mpox is an illness caused by the monkeypox virus, a species of the genus Orthopoxvirus, that can be transmitted to humans through contacts with someone who is infectious, with contaminated materials, or with infected animals.

Expanding access to diagnostic services is urgently needed as tests are essential to critical measures such as strengthened laboratory capacity, improved case investigation, contact tracing, surveillance data collection, and timely reporting. As a package, these help countries identify chains of transmission, detect cases early, prevent further spread, and monitor the virus in real-time. The establishment of Emergency Use Listing procedures for mpox diagnostic tests will help advance towards this goal.

 

WHO and International Paralympic Committee team up to highlight power of assistive technology at Paris 2024 Paralympics

WHO news - Wed, 08/28/2024 - 11:51

The World Health Organization (WHO) and International Paralympic Committee (IPC) are joining forces to highlight the transformative impact of assistive technology on sports during the Paris 2024 Paralympic Games. The "Equipped for equity" campaign emphasizes the crucial role of assistive technology for Paralympic athletes to advocate for concerted global action to improve access to these essential health products.

Throughout the Games, WHO and IPC will leverage the Paralympics platform to share messages and information focused on the importance of assistive technology, how athletes use it, and why universal access is essential. Examples of assistive technology used by Paralympians include: running blades, wheelchairs, and release braces in archery.

The “Equipped for equity” campaign will also feature personal stories from athletes who rely on assistive technology for sport and in daily life and highlight national successes in advancing access to these critical health products.

“The Paralympics show us what is possible, and the important role that assistive technology plays for these extraordinary athletes,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. “But around the world, many people still do not have access to crucial assistive technology, due to its high cost and low availability. We call on governments, donors, and civil society to prioritise these neglected but critical products, by integrating them in primary care programmes as part of their journey towards universal health coverage.”

Andrew Parsons, President, IPC noted, “The Paralympic Games are one of the only global events that put persons with disabilities front and centre, and in many events highlight how assistive technology can support athletes to compete at the highest level. These technologies allow them to redefine what is possible in sports and inspire millions around the world.”

“While we get ready to celebrate incredible athletic success, it is critical to remember that access to assistive technology remains a significant concern. We must advocate for more affordable and accessible solutions globally, ensuring that everyone, regardless of where they live, has the opportunity to lead a full life and contribute to society.”

WHO estimates that access to assistive technology remains severely limited in many parts of the world, with more than 2.5 billion people in need of assistive technology across the world. For instance, only 5-35% of the 80 million people who need a wheelchair have access to one, depending on where they live, and only 10% of the global demand for hearing aids is currently met. Without access to assistive technology, persons with disabilities are denied the right to participate in all aspects of life, and are also more at risk of exclusion, isolation and poverty.

The "Equipped for equity" campaign will showcase examples like Zimbabwe’s recent tax exemption on assistive technology and the pre-Paralympic tax reductions on assistive technology for sports in France and Japan. By highlighting these initiatives, the campaign calls on countries to implement similar initiatives and integrate assistive technology into primary health care and universal health coverage.

Measures to make assistive technology more accessible and affordable are essential not only for empowering individuals to participate fully in life but also for driving broader societal and economic development. Expanding access to quality-assured, safe, and affordable assistive technology reduces health and welfare costs such as recurrent hospital admissions, and promotes a more productive labour force, indirectly stimulating economic growth.

WHO is also supporting the IPC and the Government of France to ensure a healthy and safe environment for all athletes and spectators at the Paris 2024 Paralympics. Joint public health advice, developed with the European Centre for Disease Prevention and Control, has been provided to support travellers attending the Games.

EVD-LabNet webinar on laboratory aspects of MPXV detection

ECDC - News - Wed, 08/28/2024 - 11:36
In response to the PHEIC for Mpox, EVD-LabNet is organising a webinar on laboratory aspects of MPXV detection on Friday 30 August 2024 at 9:30-11:30.
Categories: C.D.C. (Europe)

Fourteen African countries, key partners unite to provide critical resources for health in WHO’s first-ever Investment Round

WHO news - Tue, 08/27/2024 - 22:45

In an unprecedented show of unity in support of the World Health Organization, 14 African countries and many partners pledged over US$ 45 million to the WHO Investment Round, a three-month-old initiative aimed at generating sustainable financing for the organization at the center of the global health architecture.  The commitments were made during the World Health Organization (WHO) Regional Committee for Africa, with heads of state and government from across the continent underscoring the importance of investing in global health and ensuring a strong WHO. 

“I thank our African Region Member States for actively supporting WHO’s first Investment Round to mobilize predictable and flexible resources needed for our core work over the next four years,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. “Full, sustainable funding will enable WHO to support countries better in their work to build healthier, more resilient, and more prosperous populations.” 

The countries and partners came together for the historic event aimed at sustainably funding WHO and thus enabling it to more effectively fulfil its mandate and advance key objectives to promote, provide and protect health and well-being for all. The countries included Botswana, Cabo Verde, Chad, Congo, Ethiopia, Gambia, Mauritius, Namibia, Niger, Rwanda, Senegal, Seychelles, South Africa, and the United Republic of Tanzania.  

Many partners joined Members States in making commitments of support to WHO and committing to providing pledges later in the year, including Helmsley Charitable Trust, World Diabetes Foundation, Roche, Kuwait Fund for Arab Economic Development, the Bill & Melinda Gates Foundation, African Development Bank and the WHO Foundation.  

“A strong, predictable and sustainably financed WHO is essential for our region and the world to meet the multiple health threats we face; and support the prevention of disease based on the vast evidence at our disposal,” said Dr Matshidiso Moeti, WHO Regional Director for Africa. “Every pledge and every partnership counts. Together, we can achieve a future where health and well-being are accessible to all.”  

The WHO Investment Round will continue in the coming months and feature key pledging moments around the world. Learn more about the WHO investment Round.  

Launched at the World Health Assembly in May 2024, the Investment Round aims to generate contributions that are flexible and thereby aligned with WHO’s strategy as approved by its Member States; predictably provided at the start of the four-year budget cycle to enable strategic decision-making; and resilient in that they will derive from a larger, more diverse set of donors.

Global strategic preparedness and response plan launched by WHO to contain mpox outbreak

WHO news - Mon, 08/26/2024 - 13:33

The World Health Organization (WHO) today launched a global Strategic Preparedness and Response Plan to stop outbreaks of human-to-human transmission of mpox through coordinated global, regional, and national efforts. This follows the declaration of a public health emergency of international concern by the WHO Director-General on 14 August.

The current plan is subject to inputs by Member States, who were briefed on the plan on Friday, 23 August.

The plan covers the six-month period of September 2024-February 2025, envisioning a US$135 million funding need for the response by WHO, Member States, partners including Africa Centres for Disease Control and Prevention (Africa CDC), communities, and researchers, among others.

A funding appeal for what WHO needs to deliver on the plan will be launched shortly.

The plan, which builds on the temporary recommendations and standing recommendations issued by the WHO Director-General, focuses on implementing comprehensive surveillance, prevention, readiness and response strategies; advancing research and equitable access to medical countermeasures like diagnostic tests and vaccines; minimizing animal-to-human transmission; and empowering communities to actively participate in outbreak prevention and control.

Strategic vaccination efforts will focus on individuals at the highest risk, including close contacts of recent cases and healthcare workers, to interrupt transmission chains.

At the global-level, the emphasis is on strategic leadership, timely evidence-based guidance, and access to medical countermeasures for the most at-risk groups in affected countries.

WHO is working with a broad range of international, regional, national and local partners and networks to enhance coordination across key areas of preparedness, readiness and response. This includes engagement with the ACT-Accelerator Principals group; the Standing Committee on Health Emergency Prevention, Preparedness and Response; the R&D Blueprint for Epidemics; and the interim Medical Counter Measures Network (i-MCM Net).

The WHO R&D Blueprint, along with Africa CDC, Coalition for Epidemic Preparedness Innovations (CEPI) and National Institute of Allergy and Infectious Diseases, will host a virtual scientific conference on 29-30 August 2024 to align mpox research with outbreak control goals.

“The mpox outbreaks in the Democratic Republic of the Congo and neighbouring countries can be controlled, and can be stopped,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. “Doing so requires a comprehensive and coordinated plan of action between international agencies and national and local partners, civil society, researchers and manufacturers, and our Member States. This SPRP provides that plan, based on the principles of equity, global solidarity, community empowerment, human rights, and coordination across sectors.”

WHO headquarters and regional offices have established incident management support teams to lead preparedness, readiness and response activities, and are significantly scaling up staff in affected countries.

Within the Africa Region, where need is greatest, the WHO Regional Office for Africa (AFRO) in collaboration with Africa CDC, will jointly spearhead the coordination of mpox response efforts. WHO AFRO and Africa CDC have agreed on a one-plan, one-budget approach as part of the Africa Continental Mpox Strategic Preparedness and Response Plan, currently under preparation.

At the national and sub-national level, health authorities will adapt strategies in response to current epidemiological trends.

 

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