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In early 2022, ECDC launched a comprehensive strategic foresight initiative to consider and prepare for future public health challenges.

A global report published by the World Health Organization (WHO) highlights that the underlying causes of ill health often stem from factors beyond the health sector, such as lack of quality housing, education and job opportunities.

The Jubilee 2025, also known as a Holy Year, will take place in Rome and the Vatican City, Italy, spanning 2025 and concluding on 6 January 2026.

On World Hand Hygiene Day, a new ECDC survey* reveals that 3.1% of the residents in long-term care facilities (LTCFs) had at least one healthcare-associated infection (HAI) at the time of the study.

"WHO is committed to working with the IPU to inform and support parliaments on global health priorities. We encourage all of you to join your national delegation at WHA78 to make your voice heard and to translate global health decisions into national-level actions," affirmed Dr Tedros in his remarks to the delegates.

On World Hand Hygiene Day, the WHO emphasizes the critical role of hand hygiene in preventing infections, stating that gloves are not a substitute for proper handwashing.

Today marks an important milestone for ECDC’s cooperation with countries under EU’s Enlargement policy. After 14 years of close collaboration, on 28 April 2025 ECDC formalised its cooperation through the signing of Memoranda of Understanding with Albania, Kosovo*, Montenegro, and with the new EU candidate country, Moldova.

The Global Outbreak Alert and Response Network (GOARN), an initiative coordinated by the World Health Organization (WHO), marks its 25th anniversary today. Since its inception in April 2000, the network has been at the forefront of the global fight against health emergencies. By leveraging the expertise of global partners – facilitating alerts, deploying rapid support capacities, and strengthening capacities – it has significantly enhanced country-level operations and strengthened regional development, playing a critical role in health preparedness and response.

“GOARN is a vital part of the global health architecture,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. “Through the network, countries get the expert support they need to respond to health emergencies, and to enhance their own capacities for preparedness and response. This means faster, more effective responses and more lives saved.”

GOARN was created in response to the need for better coordination during global health emergencies. While many partner organizations were sending teams to assist during emergencies, there was a lack of coordination which hindered the overall effectiveness of these responses. It was also clear that no single institution could address all components of a response alone. GOARN was thus born following an international meeting organized by WHO in Geneva on 26–28 April 2000. Some 121 representatives from 67 partner institutions discussed the growing challenge of epidemic-prone and emerging diseases, and the urgent need to build a global network based on existing partnerships to address these threats.

In October 2000, GOARN played a key role in responding to the major Ebola outbreak in Gulu, Uganda – marking a significant milestone in what would evolve into a quarter-century of pivotal global health responses.

“As one of the first responders deployed during the Ebola outbreak in Uganda 25 years ago, I witnessed firsthand the evolution of our response efforts and GOARN’s role,” said Dr Mike Ryan, Executive Director of WHO’s Health Emergencies Programme and Deputy Director-General of WHO.  “When I returned to Uganda earlier this year for another Ebola response, I was immensely proud to see how strong the national capacities have become, led by the Ministry of Health with the support of WHO and GOARN partners. GOARN is an example of how multilateralism works to save lives. To this day, I wear the orange GOARN lanyard alongside my blue WHO one to show my respect for and pride in this network.”

GOARN leverages the expertise of its partner institutions to address global health challenges. Operating as a unified international community, the network has responded swiftly and effectively to public health threats by deploying technical experts to ensure the right expertise is in the right place at the right time. GOARN's goal is to strengthen countries' capacities and help build strong, resilient systems for response to emergencies.

GOARN ensures that the experts are well-trained and equipped with the right skills before they’re deployed where they are needed most, fostering seamless collaboration for swift, coordinated, and impactful responses.

GOARN has now grown into a network of over 310 institutions, including national public health agencies, nongovernmental organizations, UN agencies, academic, and other technical organizations. GOARN has responded to over 175 public health emergencies in 114 countries, deploying more than 3645 international responders who integrate within national responses, collaborating with thousands of national professionals to strengthen and enhance local efforts. The network has tackled major global public health events, including outbreaks of SARS, Ebola virus disease, Marburg virus disease, COVID-19, mpox, cholera, yellow fever, disasters such as floods and earthquakes, and war. GOARN has deployed expertise in epidemiology, disease surveillance, case management, clinical care, infection prevention and control, risk communication and community engagement, and others. These efforts have also delivered hands-on training to hundreds of national teams, bolstering their immediate response capacity and long-term resilience.

"Looking back over the past 25 years, it’s remarkable to see how GOARN has evolved from a visionary concept to an indispensable network in the global health emergency landscape,” said Ray R. Arthur, PhD, Director, Global Disease Detection Operations Center, CDC (retired) and Former Chair of the GOARN Steering Committee. “As an early participant in establishing the network and as former chair of the Steering Committee, I witnessed firsthand the commitment and collaboration that drove the network’s success. GOARN has not only facilitated rapid response to public health emergencies but has also been instrumental in strengthening global health, ensuring that countries are better prepared for the challenges of tomorrow. It’s an honour to see the network continue to grow and play such a vital role in protecting public health worldwide."

Today, GOARN is a vital pillar in the Global Health Emergency Corps ensuring a well-coordinated health emergency workforce, centered in countries and connected regionally and globally. The 25-year milestone marks a significant evolution of GOARN’s role in preparedness and response. Rather than deploying large numbers of international professionals across every field, GOARN now brings in only the necessary expertise to address critical gaps on the ground. Paired with the focus on capacity strengthening and training initiates, GOARN has demonstrated the effectiveness of its mandate and efforts empowering countries to manage emergencies themselves.

GOARN calls on all Member States, partners and the global community to continue working together to build a global health emergency architecture that is resilient, equitable, and capable of addressing future health challenges.
 

Voices from GOARN, past and present

Dr Mohannad Al-Nsour, Executive Director, Eastern Mediterranean Public Health Network (EMPHNET), current Chair of the GOARN Steering Committee:
“As the world faces the growing threats of epidemics, conflict, and humanitarian crises, GOARN’s role has never been more vital. The network is being called to respond in increasingly complex environments – where conflict is more widespread, and public health emergencies unfold alongside deep humanitarian challenges. GOARN must continue to evolve, expanding its reach and strengthening collaboration to meet these urgent needs.”

Daniela Garone, Infectious Diseases Specialist and International Medical Coordinator, Médecins Sans Frontières, current Co-Deputy Chairs of the GOARN Steering Committee and Dr Edmund Newman, Director, UK Public Health Rapid Support Team (UK-PHRST):
"Reflecting on GOARN’s 25 years of advancing global health emergency preparedness and response, we are proud to be active partners of a network that has been instrumental in saving lives and strengthening health response systems around the world. From its humble beginnings to its current role as a vital pillar in global health response, GOARN has demonstrated the power of collaboration and expertise in tackling public health emergencies. As we look to the future, we remain committed to supporting countries in building resilient public health systems and ensuring that our collective efforts continue to evolve in response to the growing challenges of global health. Together, we will continue to foster stronger partnerships and be ready for whatever comes next."

Myriam Henkens MD, MPH, Senior Health Adviser, Médecins Sans Frontières, former member of GOARN Steering Committee:
“For 25 years, GOARN has been a cornerstone in the global response to health emergencies. As a proud participant, MSF has been working alongside GOARN to strengthen health systems and ensure a more effective global response to the challenges of tomorrow. The collaborative spirit and shared expertise across the network have made a real difference in the field, and I’m proud to have been part of this journey.”

Gail Carson, Director of Network Development at ISARIC Pandemic Sciences Institute, University of Oxford and former Chair of the GOARN Steering Committee (2022–2024):
“Serving as Chair of the GOARN Steering Committee from 2022 to 2024 was one of the greatest honours of my career. But my connection to this network goes back much further—to GOARN’s first response to Ebola in Uganda. Over the past 25 years, I’ve seen firsthand how this global community of experts supports countries in times of crisis, delivering trusted, timely, and lifesaving technical assistance. Today, GOARN continues to evolve to meet new and complex challenges. What hasn’t changed is its core strength: GOARN remains the partner you can count on when a health emergency hits.”

John S Mackenzie, Emeritus Professor and former Chair of the GOARN Steering Committee:
“GOARN was born from a visionary belief that global outbreak response could be stronger through coordinated action. I was proud to serve on its first Steering Committee, and those 14 years remain among the most fulfilling of my career. GOARN continues to grow as a powerful force in global public health – driven by collaboration, expertise, and an enduring spirit of service.”

Pat Drury, former GOARN Manager:
“GOARN has been more than just a professional milestone—it has been a journey of saving lives and making a real difference in the face of some of the world’s most challenging outbreaks, from Ebola, and SARS to COVID-19. The network’s strength is its ability to connect people, and institutions, knowledge and expertise in real time, turning alerts into rapid responses. As the challenges have grown, so have the stakes. In an increasingly polarised world, GOARN’s role in mobilizing science, and fostering trust has never been more vital. Congratulations on 25 years of extraordinary impact, and thank you to the countless individuals who make this mission possible.”

 

Marking European Immunization Week (EIW) 2025, ECDC highlights the risks of suboptimal vaccination coverage in Europe and publishes a set of operational tools that public health authorities can use to improve vaccination acceptance and uptake.

Urgent measures are needed to curtail the rising “medicalization” of female genital mutilation (FGM) and to engage health workers to prevent the practice, according to a new guideline published today by the World Health Organization (WHO).

European Immunization Week (EIW), marked annually during the last week of April, is an initiative led by the World Health Organization (WHO) to raise awareness about the benefits of immunisation as a vital part to prevent diseases and protect life.

Between 23 and 24 April 2025, the European Centre for Disease Prevention and Control (ECDC) carried out a technical visit to Moldova, following a request from the country’s national public health authorities.

Between 7 and 11 April, ECDC visited the WHO Academy together with Africa CDC.

On World Malaria Day, the World Health Organization (WHO) is calling for revitalized efforts at all levels, from global policy to community action, to accelerate progress towards malaria elimination.

In the late 1990s, world leaders laid the foundation for remarkable progress in global malaria control, including preventing more than 2 billion cases of malaria and nearly 13 million deaths since 2000.

To date, WHO has certified 45 countries and 1 territory as malaria-free, and many countries with a low burden of malaria continue to move steadily towards the goal of elimination. Of the remaining 83 malaria-endemic countries, 25 reported fewer than 10 cases of the disease in 2023.

However, as history has shown, these gains are fragile.

“The history of malaria teaches us a harsh lesson: when we divert our attention, the disease resurges, taking its greatest toll on the most vulnerable,” said WHO Director-General Dr Tedros Adhanom Ghebreyesus. “But the same history also shows us what’s possible: with strong political commitment, sustained investment, multisectoral action and community engagement, malaria can be defeated.”

Investments in new interventions drive progress

Years of investment in the development and deployment of new malaria vaccines and next-generation tools to prevent and control malaria are paying off.

On World Malaria Day, Mali will join 19 other African countries in introducing malaria vaccines—a vital step towards protecting young children from one of the continent’s most deadly diseases. The large-scale rollout of malaria vaccines in Africa is expected to save tens of thousands of young lives every year.

Meanwhile, the expanded use of a new generation of insecticide-treated nets is poised to lower the disease burden. According to the latest World malaria report, these new nets—which have greater impact against malaria than the standard pyrethroid-only nets—accounted for nearly 80% of all nets delivered in sub-Saharan Africa in 2023, up from 59% the previous year.

Progress against malaria under threat

Despite significant gains, malaria remains a major public health challenge, with nearly 600 000 lives lost to the disease in 2023 alone. The African Region is hardest hit, shouldering an estimated 95% of the malaria burden each year.

In many areas, progress has been hampered by fragile health systems and rising threats such as drug and insecticide resistance. Many at-risk groups continue to miss out on the services they need to prevent, detect and treat malaria. Climate change, conflict, poverty and population displacement are compounding these challenges.

WHO recently warned that the 2025 funding cuts could further derail progress in many endemic countries, putting millions of additional lives at risk. Of the 64 WHO Country Offices in malaria-endemic countries that took part in a recent WHO stock take assessment, more than half reported moderate or severe disruptions to malaria services.

Renewed call to protect hard-won gains

World Malaria Day 2025 - under the theme, “Malaria ends with us: reinvest, reimagine, reignite” - is calling for stepped up political and financial commitment to protect the hard-won gains against malaria.

To reinvest, WHO joins partners and civil society in calling on malaria-endemic countries to boost domestic spending, particularly in primary health care, so that all at-risk populations can access the services they need to prevent, detect and treat malaria. The successful replenishments of the Global Fund and Gavi, the Vaccine Alliance, are also critical to financing malaria programmes and interventions, and accelerating progress towards the targets set in the WHO Global technical strategy for malaria 2016-2030.

Addressing current challenges in global malaria control will also require a reimagined response through innovative tools, strategies and partnerships. New and more effective antimalarial drugs are needed, as all well as advancements in service delivery, diagnostics, insecticides, vaccines and vector control methods.

More countries are making malaria control and elimination a national priority, including through the Yaoundé Declaration, signed in March 2024 by African Ministers of Health from 11 high burden countries.

“Ministers committed to strengthening their health systems, stepping up domestic resources, enhancing multisectoral action and ensuring a robust accountability mechanism,” notes Dr Daniel Ngamije, Director of the WHO Global Malaria Programme. “This is the kind of leadership the world must rally behind.”

Reigniting commitment at all levels – from communities and frontline health workers to governments, researchers, the private sector innovators and donors – will be critical to curbing and, ultimately, ending malaria.

Notes to the editor:

For more information on the WHO World Malaria Day campaign, visit: https://www.who.int/campaigns/world-malaria-day/2025

 

Immunization efforts are under growing threat as misinformation, population growth, humanitarian crises and funding cuts jeopardize progress and leave millions of children, adolescents and adults at risk, warn WHO, UNICEF, and Gavi during World Immunization Week, 24–30 April.

Outbreaks of vaccine-preventable diseases such as measles, meningitis and yellow fever are rising globally, and diseases like diphtheria, that have long been held at bay or virtually disappeared in many countries, are at risk of re-emerging. In response, the agencies are calling for urgent and sustained political attention and investment to strengthen immunization programmes and protect significant progress achieved in reducing child mortality over the past 50 years.

“Vaccines have saved more than 150 million lives over the past five decades,” said WHO Director-General, Dr Tedros Adhanom Ghebreyesus. “Funding cuts to global health have put these hard-won gains in jeopardy. Outbreaks of vaccine-preventable diseases are increasing around the world, putting lives at risk and exposing countries to increased costs in treating diseases and responding to outbreaks. Countries with limited resources must invest in the highest-impact interventions – and that includes vaccines.”

Rising outbreaks and strained health systems

Measles is making an especially dangerous comeback. The number of cases has been increasing year on year since 2021, tracking the reductions in immunization coverage that occurred during and since the COVID-19 pandemic in many communities. Measles cases reached an estimated 10.3 million in 2023, a 20% increase compared to 2022.

The agencies warn that this upward trend likely continued into 2024 and 2025, as outbreaks have intensified around the world. In the past 12 months, 138 countries have reported measles cases, with 61 experiencing large or disruptive outbreaks – the highest number observed in any 12-month period since 2019.

Meningitis cases in Africa also rose sharply in 2024, and the upward trend has continued into 2025. In the first three months of this year alone, more than 5500 suspected cases and nearly 300 deaths were reported in 22 countries. This follows approximately 26 000 cases and almost 1400 deaths across 24 countries last year.

Yellow fever cases in the African region are also climbing, with 124 confirmed cases reported in 12 countries in 2024. This comes after dramatic declines in the disease over the past decade, thanks to global vaccine stockpiles and use of yellow fever vaccine in routine immunization programmes. In the WHO Region of the Americas, yellow fever outbreaks have been confirmed since the beginning of this year, with a total of 131 cases in 4 countries.

These outbreaks come amidst global funding cuts. A recent WHO rapid stock take with 108 country offices of WHO – mostly in low- and lower-middle-income countries – shows that nearly half of those countries are facing moderate to severe disruptions to vaccination campaigns, routine immunization and access to supplies due to reduced donor funding. Disease surveillance, including for vaccine-preventable diseases, is also impacted in more than half of the countries surveyed.

At the same time, the number of children missing routine vaccinations has been increasing in recent years, even as countries make efforts to catch up children missed during the pandemic. In 2023, an estimated 14.5 million children missed all of their routine vaccine doses – up from 13.9 million in 2022 and 12.9 million in 2019. Over half of these children live in countries facing conflict, fragility, or instability, where access to basic health services is often disrupted.

“The global funding crisis is severely limiting our ability to vaccinate over 15 million vulnerable children in fragile and conflict-affected countries against measles,” said UNICEF Executive Director Catherine Russell. “Immunization services, disease surveillance, and the outbreak response in nearly 50 countries are already being disrupted – with setbacks at a similar level to what we saw during COVID-19. We cannot afford to lose ground in the fight against preventable diseases.”

Continued investment in the ‘Big Catch-Up initiative’, launched in 2023 to reach children who missed vaccines during the COVID-19 pandemic, and other routine immunization programmes will be critical.

How immunization addresses these challenges

Joint efforts by WHO, UNICEF, Gavi and partners have helped countries expand access to vaccines and strengthen immunization systems through primary health care, even in the face of mounting challenges. Every year, vaccines save nearly 4.2 million lives against 14 diseases – with nearly half of these lives saved in the African Region.

Vaccination campaigns have led to the elimination of meningitis A in Africa’s meningitis belt, while a new vaccine that protects against five strains of meningitis holds promise for broader protection, with efforts underway to expand its use for outbreak response and prevention.

Progress has also been made in reducing yellow fever cases and deaths through increasing routine immunization coverage and emergency vaccine stockpiles, but recent outbreaks in Africa and in the Region of the Americas highlight the risks in areas with no reported cases in the past, low routine vaccination coverage and gaps in preventive campaigns.

In addition, the past two years have seen substantial progress in other areas of immunization. In the African Region, which has the highest cervical cancer burden in the world, HPV vaccine coverage nearly doubled between 2020 and 2023 from 21% to 40%, reflecting a concerted global effort towards eliminating cervical cancer. The progress in immunization also includes increases in global coverage of pneumococcal conjugate vaccines, particularly in the South-East Asia Region, alongside introductions in Chad and Somalia, countries with high disease burden.

Another milestone is the sub-national introduction of malaria vaccines in nearly 20 African countries, laying the foundation to save half a million additional lives by 2035 as more countries adopt the vaccines and scale-up accelerates as part of the tools to fight malaria.

Call to action

UNICEF, WHO, and Gavi urgently call for parents, the public, and politicians to strengthen support for immunization. The agencies emphasize the need for sustained investment in vaccines and immunization programmes and urge countries to honour their commitments to the Immunization Agenda 2030 (IA2030).

As part of integrated primary health-care systems, vaccination can protect against diseases and connect families to other essential care, such as antenatal care, nutrition or malaria screening. Immunization is a ‘best buy’ in health with a return on investment of $54 for every dollar invested and provides a foundation for future prosperity and health security.

“Increasing outbreaks of highly infectious diseases are a concern for the whole world. The good news is we can fight back, and Gavi’s next strategic period has a clear plan to bolster our defences by expanding investments in global vaccine stockpiles and rolling out targeted preventive vaccination in countries most impacted by meningitis, yellow fever and measles,” said Dr Sania Nishtar, CEO of Gavi, the Vaccine Alliance. “These vital activities, however, will be at risk if Gavi is not fully funded for the next five years and we call on our donors to support our mission in the interests of keeping everyone, everywhere, safer from preventable diseases.”

Gavi’s upcoming high-level pledging summit taking place on 25 June 2025 seeks to raise at least US$ 9 billion from our donors to fund our ambitious strategy to protect 500 million children, saving at least 8 million lives from 2026–2030.

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Notes to editor:

Download multimedia content here: https://weshare.unicef.org/Package/2AM4086M4S1G

About WHO
Dedicated to the health and well-being of all people and guided by science, the World Health Organization leads and champions global efforts to give everyone, everywhere, an equal chance at a safe and healthy life. We are the UN agency for health. We connect nations, partners and people on the front lines in 150+ locations – leading the world’s response to health emergencies, preventing disease, addressing the root causes of health issues and expanding access to medicines and health care. Our mission is to promote health, keep the world safe and serve the vulnerable. www.who.int

About UNICEF
UNICEF works in some of the world's toughest places, to reach the world's most disadvantaged children. Across more than 190 countries and territories, we work for every child, everywhere, to build a better world for everyone. For more information about UNICEF and its work, visit: www.unicef.org.

About Gavi, the Vaccine Alliance
Gavi, the Vaccine Alliance is a public-private partnership that helps vaccinate more than half the world’s children against some of the world’s deadliest diseases. Since its inception in 2000, Gavi has helped to immunize a whole generation – over 1.1 billion children – and prevented more than 18.8 million future deaths, helping to halve child mortality in 78 lower income countries. Gavi also plays a key role in improving global health security by supporting health systems as well as funding global stockpiles for Ebola, cholera, meningococcal and yellow fever vaccines. After two decades of progress, Gavi is now focused on protecting the next generation, above all the zero-dose children who have not received even a single vaccine shot. The Vaccine Alliance employs innovative finance and the latest technology – from drones to biometrics – to save lives, prevent outbreaks before they can spread and help countries on the road to self-sufficiency. Learn more at www.gavi.org.

 

Although progress has been made towards SDG target 3.3 to end the epidemics of HIV, TB, and combatting viral hepatitis B and C and STIs by 2030, the EU/EEA is off track for many of the targets.

In a bid to tackle the leading cause of death globally among 15–19-year-old girls, the World Health Organization (WHO) today released a new guideline aimed at preventing adolescent pregnancy and its significant related health complications.

Among other strategies, the guideline urges rapid action to end child marriage, extend girls’ schooling, and improve access to sexual and reproductive health services and information – all critical factors for reducing early pregnancies among teenagers around the world.

“Early pregnancies can have serious physical and psychological consequences for girls and young women, and often reflect fundamental inequalities that affect their ability to shape their relationships and their lives,” said Dr Pascale Allotey, Director of Sexual and Reproductive Health and Research at WHO and the United Nations’ Special Programme in Human Reproduction (HRP). “Tackling this issue therefore means creating conditions where girls and young women can thrive – by ensuring they can stay in school, be protected from violence and coercion, access sexual and reproductive health services that uphold their rights, and have real choices about their futures.”

More than 21 million adolescent girls become pregnant each year in low and middle-income countries, around half of which are unintended. With impacts on girls’ education, social connection and future employment prospects, early pregnancy can create cycles of intergenerational poverty that become difficult to break. It also brings serious health risks, including relatively higher rates of infections and preterm births as well as complications from unsafe abortions – linked to particular challenges in accessing safe and respectful care.

Reasons for early pregnancy are varied and interrelated, including gender inequities, poverty, lack of opportunity and inability to access sexual and reproductive health services. There is a strong correlation with child marriage: in low- and middle-income countries, 9 in 10 adolescent births take place among girls who were married before the age of 18.

The guideline recommends holistic efforts to provide viable alternatives to early marriage by strengthening girls’ education, savings and employment prospects. If all girls finished their secondary schooling, it has been estimated that child marriages could be reduced by as much as two thirds. For girls at highest risk, the guideline recommends considering incentives to support secondary school completion, such as targeted financial stipends or scholarship programmes. The guideline also recommends laws to prohibit marriage below the age of 18, consistent with human rights standards, and community engagement to prevent the practice.

“Early marriage denies girls their childhood and has severe consequences for their health,” said Dr Sheri Bastien, Scientist for Adolescent Sexual and Reproductive Health at WHO. “Education is critical to change the future for young girls, while empowering adolescents – both boys and girls – to understand consent, take charge of their health, and challenge the major gender inequalities that continue to drive high rates of child marriage and early pregnancy in many parts of the world.”

The recommendations highlight the need to ensure adolescents can access high quality, adolescent-responsive sexual and reproductive health services including contraceptive options. In some countries, consent from an adult is required to access services, which is a significant barrier to their use. Young girls who get pregnant also need to be able to access high quality and respectful healthcare during and after pregnancy and birth, free from stigma and discrimination, as well as safe abortion care.

Finally, comprehensive sexuality education is essential for both boys and girls to ensure they know where to access such services and how to use different types of contraception. It has been shown to reduce early pregnancies, delay the onset of sexual activity, and improve adolescents’ knowledge about their bodies and reproductive health. 

This guideline updates an earlier edition of the guideline on adolescent pregnancy prevention from 2011 and focuses particularly on preventing child marriage and improving adolescents’ access to and use of contraception. It complements WHO’s related guidance around health services for adolescents, comprehensive sexuality education and gender-based violence.

Globally, there has been progress in reducing adolescent pregnancies and births. In 2021, an estimated 1 in 25 girls gave birth before the age of 20, compared to 1 in 15 two decades prior. There remain significant disparities. In some countries, close to 1 in 10 adolescent girls (15–19 years) give birth each year.

Every month ECDC provides detailed epidemiological overview of the worldwide transmission of mpox in its weekly threat report.

Africa CDC and WHO have updated their joint Continental Response Plan for the mpox emergency as the disease continues to affect new areas. The revised strategy focuses on controlling outbreaks, while expanding vaccination coverage and transitioning toward a longer-term, sustainable response. 

Mpox is a viral illness that spreads between people, mainly through close contact. It causes painful skin and mucosal lesions, often accompanied by fever, headache, muscle aches, back pain, fatigue, and swollen lymph nodes. The disease can be debilitating and disfiguring. 

Historically a zoonotic disease transmitted from infected animals, mpox has increasingly shown a tendency to spread between people. In 2022, a variant of the virus, clade IIb, began spreading globally through sexual contact. Since late 2023, yet another viral strain, clade Ib, began spreading through sexual networks and within households and through close contact. This prompted Africa CDC to declare a Public Health Emergency of Continental Security and the WHO Director-General to declare a Public Health Emergency of International Concern in August 2024. 

By August 2024, the virus had begun spreading from the Democratic Republic of the Congo to 4 neighbouring countries. Since then, 28 countries around the world have reported cases of mpox due to clade Ib. Outside Africa, cases remain largely travel-related. However, within Africa, in addition to transmission in Burundi, the Democratic Republic of the Congo, Kenya, Rwanda and Uganda, local transmission has now been documented in additional countries including the Republic of the Congo, South Africa, South Sudan, the United Republic of Tanzania and Zambia. 

Since the declaration of the emergency, both regional and global support has increased, particularly for the Democratic Republic of the Congo, the epicentre of the outbreak. The Africa CDC and WHO Joint Continental Mpox Plan has guided these efforts, focusing on ten key pillars: coordination, risk communication and community engagement, disease surveillance, laboratory capacity, clinical management, infection prevention and control, vaccination, research, logistics, and maintaining essential health services. 

Vaccination efforts are underway, with more than 650 000 doses administered in 6 countries, 90% of which have been administered in the Democratic Republic of the Congo. Overall, over a million doses have been delivered to 10 countries, with efforts ongoing to secure additional vaccine supplies. 

Diagnostic testing capacity in the Democratic Republic of the Congo has grown significantly, driven by the expansion of laboratory infrastructure - from 2 laboratories in late 2023 to 23 laboratories in 12 provinces today. With new, near-point-of-care tests currently being rolled out in the country, capacity is expected to increase even further. 

Despite this progress, major challenges remain. Ongoing conflict and insecurity in eastern Democratic Republic of the Congo, where the incidence of mpox remains high, as well as humanitarian aid cuts, continue to limit the public health response and restrict access to essential services. Across countries and partners, over US$ 220 million is needed to fill funding gaps for the mpox response.  

The updated Continental Response Plan calls for intensified efforts to bring outbreaks under control, while also taking concrete actions to integrate mpox into routine health services.  

Along with the Continental Response Plan for Africa, WHO has updated the global strategic plan to curb - and where feasible, to stop - human-to-human transmission of mpox. In the first two months of 2025, 60 countries reported mpox, with the majority of cases and deaths reported from the African continent.  The joint Continental Response Plan is aligned with the global strategy. 

Africa CDC and WHO continue to work closely with national governments, local communities, and partners to curb transmission, control the outbreak, and build longer-term resilience within public health systems. 

 

After more than three years of intensive negotiations, WHO Member States took a major step forward in efforts to make the world safer from pandemics, by forging a draft agreement for consideration at the upcoming World Health Assembly in May. The proposal aims to strengthen global collaboration on prevention, preparedness and response to future pandemic threats.

In December 2021, at the height of the COVID-19 pandemic, WHO Member States established the Intergovernmental Negotiating Body (INB)to draft and negotiate a convention, agreement or other international instrument, under the WHO Constitution, to strengthen pandemic prevention, preparedness and response.

Following 13 formal rounds of meetings, nine of which were extended, and many informal and intersessional negotiations on various aspects of the draft agreement, the INB today finalized a proposal for the WHO Pandemic Agreement. The outcome of the INB’s work will now be presented to the Seventy-eighth World Health Assembly for its consideration.

"The nations of the world made history in Geneva today," said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. "In reaching consensus on the Pandemic Agreement, not only did they put in place a generational accord to make the world safer, they have also demonstrated that multilateralism is alive and well, and that in our divided world, nations can still work together to find common ground, and a shared response to shared threats. I thank WHO's Member States, and their negotiating teams, for their foresight, commitment and tireless work. We look forward to the World Health Assembly's consideration of the agreement and – we hope – its adoption."

Proposals within the text developed by the INB include establishing a pathogen access and benefit sharing system; taking concrete measures on pandemic prevention, including through a One Health approach; building geographically diverse research and development capacities; facilitating the transfer of technology and related knowledge, skills and expertise for the production of pandemic-related health products; mobilizing  a skilled, trained and multidisciplinary national and global health emergency workforce; setting up a coordinating financial mechanism; taking concrete measures to strengthen preparedness, readiness and health system functions and resilience; and establishing a global supply chain and logistics network.

The proposal affirms the sovereignty of countries to address public health matters within their borders, and provides that nothing in the draft agreement shall be interpreted as providing WHO any authority to direct, order, alter or prescribe national laws or policies, or mandate States to take specific actions, such as ban or accept travellers, impose vaccination mandates or therapeutic or diagnostic measures or implement lockdowns.

Dr Tedros paid tribute to the members of the Bureau who guided the INB process: Co-Chairs Ms Precious Matsoso (South Africa) and Ambassador Anne-Claire Amprou (France), and Vice-Chairs Ambassador Tovar da Silva Nunes (Brazil), Ambassador Amr Ramadan (Egypt), Dr Viroj Tangcharoensathien (Thailand); and Ms Fleur Davies (Australia). Past members included former Co-Chair, Mr Roland Driece (the Netherlands), and former Vice-Chairs Ambassador Honsei (Japan) and Mr Ahmed Soliman (Egypt). The Director-General also acknowledged the constant support provided by WHO Secretariat colleagues.

INB Co-Chair Ms Matsoso said: “I am overjoyed by the coming together of countries, from all regions of the world, around a proposal to increase equity and, thereby, protect future generations from the suffering and losses we suffered during the COVID-19 pandemic. The negotiations, at times, have been difficult and protracted. But this monumental effort has been sustained by the shared understanding that viruses do not respect borders, that no one is safe from pandemics until everyone is safe, and that collective health security is an aspiration we deeply believe in and want to strengthen.”

Fellow INB Co-Chair, Ambassador Amprou, said the draft agreement is a major step in strengthening the global health security architecture so people of the world would be better protected from the next pandemic.

“In drafting this historic agreement, the countries of the world have demonstrated their shared commitment to preventing and protecting everyone, everywhere, from future pandemic threats,” Ambassador Amprou said. “While the commitment to prevention through the One Health approach is a major step forward in protecting populations, the response will be faster, more effective and more equitable. This is a historic agreement for health security, equity and international solidarity.”

The INB was established in December 2021, at a special session of the World Health Assembly , bringing together Member States and relevant stakeholders, including international organizations, private sector, and civil society. At the World Health Assembly in  June 2024, governments made concrete commitments to complete negotiations on a global pandemic agreement within a year. The upcoming Assembly starting 19 May 2025 will consider the proposal developed by the INB and take the final decision on whether to adopt the instrument under Article 19 of the WHO Constitution.